Drug interactions
Fluoxetine + Lornoxicam
Severity: Moderate
Fluoxetine and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an SSRI with an NSAID raises the risk of gastrointestinal bleeding beyond that of either drug alone. The risk is greater in older patients and those with prior ulcer disease.
What this interaction means in plain words
Fluoxetine and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Lornoxicam belongs to Musculoskeletal.
Why it happens
SSRI-induced depletion of platelet serotonin impairs platelet aggregation, while the NSAID inhibits platelet function and damages gastric mucosa.
What to do
Avoid the combination in high-risk patients or add a proton pump inhibitor for gastroprotection. Counsel patients to report black stools or hematemesis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Lornoxicam
Frequently asked questions
Can I take Fluoxetine with Lornoxicam?
MediHelp rates the interaction as moderate. Fluoxetine and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an SSRI with an NSAID raises the risk of gastrointestinal bleeding beyond that of either drug alone. The risk is greater in older patients and those with prior ulcer disease.
How serious is the interaction between Fluoxetine and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in high-risk patients or add a proton pump inhibitor for gastroprotection. Counsel patients to report black stools or hematemesis.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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