Drug interactions
Fluoxetine + Lurasidone
Severity: Minor
Fluoxetine and Lurasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine is a CYP2D6 inhibitor and a weak CYP3A4 inhibitor, and lurasidone is metabolized mainly by CYP3A4, so exposure may rise modestly. Additive sedation and other adverse effects may also occur.
What this interaction means in plain words
Fluoxetine and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluoxetine belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by fluoxetine/norfluoxetine, with additive CNS effects.
What to do
No routine dose change is needed; monitor for sedation, akathisia and other adverse effects when starting or adjusting therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Fluoxetine with Lurasidone?
MediHelp rates the interaction as minor. Fluoxetine and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluoxetine is a CYP2D6 inhibitor and a weak CYP3A4 inhibitor, and lurasidone is metabolized mainly by CYP3A4, so exposure may rise modestly. Additive sedation and other adverse effects may also occur.
How serious is the interaction between Fluoxetine and Lurasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for sedation, akathisia and other adverse effects when starting or adjusting therapy.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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