Drug interactions
Fluoxetine + Macimorelin
Severity: Moderate
Fluoxetine and Macimorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin can modestly prolong the QT interval, and fluoxetine may add to this effect. Taken together, they may increase the risk of torsades de pointes during diagnostic testing.
What this interaction means in plain words
Fluoxetine and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Macimorelin belongs to Endocrine.
Why it happens
Additive QT prolongation.
What to do
Where clinically possible, avoid macimorelin testing while fluoxetine is on board. Otherwise, check the ECG and electrolytes before testing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluoxetine and Macimorelin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Fluoxetine with Macimorelin?
MediHelp rates the interaction as moderate. Fluoxetine and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin can modestly prolong the QT interval, and fluoxetine may add to this effect. Taken together, they may increase the risk of torsades de pointes during diagnostic testing.
How serious is the interaction between Fluoxetine and Macimorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where clinically possible, avoid macimorelin testing while fluoxetine is on board. Otherwise, check the ECG and electrolytes before testing.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
