Drug interactions
Fluoxetine + Mefenamic acid
Severity: Moderate
Fluoxetine and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine with an NSAID raises the risk of upper gastrointestinal bleeding. Fluoxetine also inhibits CYP2C9 and could modestly raise mefenamic acid exposure.
What this interaction means in plain words
Fluoxetine and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Mefenamic acid belongs to Musculoskeletal.
Why it happens
SSRI-induced platelet serotonin depletion adds to NSAID platelet inhibition and mucosal injury.
What to do
Avoid prolonged co-use and consider a proton pump inhibitor in high-risk patients. Monitor for signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Mefenamic acid?
MediHelp rates the interaction as moderate. Fluoxetine and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine with an NSAID raises the risk of upper gastrointestinal bleeding. Fluoxetine also inhibits CYP2C9 and could modestly raise mefenamic acid exposure.
How serious is the interaction between Fluoxetine and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged co-use and consider a proton pump inhibitor in high-risk patients. Monitor for signs of GI bleeding.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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