Drug interactions
Fluoxetine + Mirabegron
Severity: Minor
Fluoxetine and Mirabegron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine is partly metabolised by CYP2D6, so mirabegron may modestly increase exposure. Fluoxetine is itself a strong CYP2D6 inhibitor, so the added effect is likely small and may increase serotonergic adverse effects.
What this interaction means in plain words
Fluoxetine and Mirabegron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluoxetine belongs to Central Nervous System; Mirabegron belongs to Genitourinary.
Why it happens
Mirabegron inhibits CYP2D6, slightly reducing fluoxetine metabolism.
What to do
No dose change is usually required; watch for increased SSRI adverse effects. Also be aware that fluoxetine can raise mirabegron exposure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mirabegron
- Digoxin + Mirabegron Major
- Flecainide + Mirabegron Major
- Mirabegron + Propafenone Major
- Mirabegron + Thioridazine Major
- Amitriptyline + Mirabegron Moderate
- Amoxapine + Mirabegron Moderate
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Mirabegron?
MediHelp rates the interaction as minor. Fluoxetine and Mirabegron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluoxetine is partly metabolised by CYP2D6, so mirabegron may modestly increase exposure. Fluoxetine is itself a strong CYP2D6 inhibitor, so the added effect is likely small and may increase serotonergic adverse effects.
How serious is the interaction between Fluoxetine and Mirabegron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required; watch for increased SSRI adverse effects. Also be aware that fluoxetine can raise mirabegron exposure.
What other medicines interact with Mirabegron?
MediHelp also lists interactions of Mirabegron with, for example, Digoxin, Flecainide, Propafenone. The full list is on the Mirabegron page.
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