Drug interactions
Fluoxetine + Omeprazole
Severity: Minor
Fluoxetine and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine and norfluoxetine inhibit CYP2C19, the main pathway for omeprazole, so omeprazole exposure may increase. This is usually well tolerated given omeprazole's wide safety margin.
What this interaction means in plain words
Fluoxetine and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluoxetine belongs to Central Nervous System; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Fluoxetine inhibition of CYP2C19 reduces omeprazole clearance.
What to do
No routine adjustment; consider a lower omeprazole dose if used long term at high doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Omeprazole?
MediHelp rates the interaction as minor. Fluoxetine and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluoxetine and norfluoxetine inhibit CYP2C19, the main pathway for omeprazole, so omeprazole exposure may increase. This is usually well tolerated given omeprazole's wide safety margin.
How serious is the interaction between Fluoxetine and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; consider a lower omeprazole dose if used long term at high doses.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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