Drug interactions
Fluoxetine + Osimertinib
Severity: Moderate
Fluoxetine and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QTc interval, so concurrent use may increase the risk of serious ventricular arrhythmias. The risk is greater with electrolyte abnormalities or structural heart disease.
What this interaction means in plain words
Fluoxetine and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Osimertinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QTc prolongation.
What to do
Monitor ECG and serum electrolytes periodically and correct abnormalities. Stop osimertinib or reassess therapy if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Fluoxetine with Osimertinib?
MediHelp rates the interaction as moderate. Fluoxetine and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QTc interval, so concurrent use may increase the risk of serious ventricular arrhythmias. The risk is greater with electrolyte abnormalities or structural heart disease.
How serious is the interaction between Fluoxetine and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum electrolytes periodically and correct abnormalities. Stop osimertinib or reassess therapy if QTc becomes markedly prolonged.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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