Drug interactions
Fluoxetine + Oxaliplatin
Severity: Moderate
Fluoxetine and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, so the combination may increase torsades de pointes risk. Patients receiving chemotherapy often also have electrolyte disturbances and vomiting that add to the risk.
What this interaction means in plain words
Fluoxetine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Oxaliplatin belongs to Oncology.
Why it happens
Additive QT interval prolongation.
What to do
Obtain a baseline ECG and check potassium, magnesium and calcium before and during oxaliplatin cycles. Correct deficits and consider an alternative antidepressant with less QT effect if the QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Fluoxetine with Oxaliplatin?
MediHelp rates the interaction as moderate. Fluoxetine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, so the combination may increase torsades de pointes risk. Patients receiving chemotherapy often also have electrolyte disturbances and vomiting that add to the risk.
How serious is the interaction between Fluoxetine and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and check potassium, magnesium and calcium before and during oxaliplatin cycles. Correct deficits and consider an alternative antidepressant with less QT effect if the QTc is prolonged.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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