Drug interactions
Fluoxetine + Peginterferon alfa 2b
Severity: Minor
Fluoxetine and Peginterferon alfa 2b: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peginterferon alfa 2b may modestly alter CYP2D6 metabolism of fluoxetine, but any change is unpredictable and probably small. Fluoxetine is also commonly used to treat interferon-related depression.
What this interaction means in plain words
Fluoxetine and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluoxetine belongs to Central Nervous System; Peginterferon alfa 2b belongs to Anti Virals.
Why it happens
Possible interferon modulation of CYP2D6; not firmly established.
What to do
Monitor mood and SSRI adverse effects. Adjust the fluoxetine dose according to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Peginterferon alfa 2b
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Peginterferon alfa 2b?
MediHelp rates the interaction as minor. Fluoxetine and Peginterferon alfa 2b have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Peginterferon alfa 2b may modestly alter CYP2D6 metabolism of fluoxetine, but any change is unpredictable and probably small. Fluoxetine is also commonly used to treat interferon-related depression.
How serious is the interaction between Fluoxetine and Peginterferon alfa 2b?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor mood and SSRI adverse effects. Adjust the fluoxetine dose according to response.
What other medicines interact with Peginterferon alfa 2b?
MediHelp also lists interactions of Peginterferon alfa 2b with, for example, Aldesleukin, Deferiprone, Pexidartinib. The full list is on the Peginterferon alfa 2b page.
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