Drug interactions
Fluoxetine + Rilpivirine
Severity: Moderate
Fluoxetine and Rilpivirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilpivirine at supratherapeutic doses prolongs the QT interval and fluoxetine can also affect cardiac repolarization. Co-administration may add to the risk of torsades de pointes, particularly in patients with other risk factors.
What this interaction means in plain words
Fluoxetine and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Rilpivirine belongs to Anti Virals.
Why it happens
Additive QT prolongation.
What to do
Consider an ECG at baseline and during therapy in patients with additional QT risk factors. Correct electrolyte abnormalities and avoid further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Fluoxetine with Rilpivirine?
MediHelp rates the interaction as moderate. Fluoxetine and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rilpivirine at supratherapeutic doses prolongs the QT interval and fluoxetine can also affect cardiac repolarization. Co-administration may add to the risk of torsades de pointes, particularly in patients with other risk factors.
How serious is the interaction between Fluoxetine and Rilpivirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an ECG at baseline and during therapy in patients with additional QT risk factors. Correct electrolyte abnormalities and avoid further QT-prolonging drugs.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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