Drug interactions
Fluoxetine + Selinexor
Severity: Minor
Fluoxetine and Selinexor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes neurological adverse effects such as dizziness, confusion and fatigue. Fluoxetine may add to CNS effects in some patients, but there is no well-defined interaction.
What this interaction means in plain words
Fluoxetine and Selinexor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluoxetine belongs to Central Nervous System; Selinexor belongs to Oncology.
Why it happens
Possible additive CNS effects; no established pharmacokinetic mechanism.
What to do
Monitor for dizziness, confusion and falls, and counsel patients to avoid driving if affected. Adjust the selinexor dose per labeling if neurological toxicity develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Fluoxetine with Selinexor?
MediHelp rates the interaction as minor. Fluoxetine and Selinexor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Selinexor commonly causes neurological adverse effects such as dizziness, confusion and fatigue. Fluoxetine may add to CNS effects in some patients, but there is no well-defined interaction.
How serious is the interaction between Fluoxetine and Selinexor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and falls, and counsel patients to avoid driving if affected. Adjust the selinexor dose per labeling if neurological toxicity develops.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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