Drug interactions
Fluoxetine + Solifenacin
Severity: Moderate
Fluoxetine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine can prolong the QT interval in some patients, and solifenacin may add to this effect. Fluoxetine is also a CYP2D6 inhibitor with weak CYP3A4 effects, though solifenacin exposure is not greatly changed.
What this interaction means in plain words
Fluoxetine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation.
What to do
Check an ECG in patients with additional QT risk factors and correct electrolyte abnormalities. Monitor for palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Solifenacin?
MediHelp rates the interaction as moderate. Fluoxetine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine can prolong the QT interval in some patients, and solifenacin may add to this effect. Fluoxetine is also a CYP2D6 inhibitor with weak CYP3A4 effects, though solifenacin exposure is not greatly changed.
How serious is the interaction between Fluoxetine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG in patients with additional QT risk factors and correct electrolyte abnormalities. Monitor for palpitations or syncope.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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