Drug interactions
Fluoxetine + Tazemetostat
Severity: Minor
Fluoxetine and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine is a weak-to-moderate CYP3A4 inhibitor and may raise tazemetostat exposure. Higher levels could increase dose-related adverse effects such as cytopenias, fatigue and gastrointestinal upset.
What this interaction means in plain words
Fluoxetine and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluoxetine belongs to Central Nervous System; Tazemetostat belongs to Miscellaneous.
Why it happens
Fluoxetine and norfluoxetine inhibit CYP3A4-mediated metabolism of tazemetostat.
What to do
Monitor for tazemetostat adverse effects and check blood counts as usual. Reduce the tazemetostat dose if toxicity emerges.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Fluoxetine with Tazemetostat?
MediHelp rates the interaction as minor. Fluoxetine and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluoxetine is a weak-to-moderate CYP3A4 inhibitor and may raise tazemetostat exposure. Higher levels could increase dose-related adverse effects such as cytopenias, fatigue and gastrointestinal upset.
How serious is the interaction between Fluoxetine and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tazemetostat adverse effects and check blood counts as usual. Reduce the tazemetostat dose if toxicity emerges.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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