Drug interactions
Fluoxetine + Tipranavir
Severity: Moderate
Fluoxetine and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, may change fluoxetine exposure through effects on hepatic enzymes. Higher fluoxetine levels could increase serotonergic and QT-related adverse effects, although the clinical data are limited.
What this interaction means in plain words
Fluoxetine and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Tipranavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted tipranavir inhibits CYP enzymes involved in fluoxetine metabolism, including CYP2D6 and CYP3A4, although tipranavir's net effect is mixed because it also induces some enzymes.
What to do
Monitor for serotonergic effects, such as agitation, tremor and diarrhea, and for QT-related symptoms when starting or stopping tipranavir. Reduce the fluoxetine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Fluoxetine with Tipranavir?
MediHelp rates the interaction as moderate. Fluoxetine and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir, given with ritonavir, may change fluoxetine exposure through effects on hepatic enzymes. Higher fluoxetine levels could increase serotonergic and QT-related adverse effects, although the clinical data are limited.
How serious is the interaction between Fluoxetine and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonergic effects, such as agitation, tremor and diarrhea, and for QT-related symptoms when starting or stopping tipranavir. Reduce the fluoxetine dose if adverse effects appear.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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