Drug interactions
Fluoxetine + Voriconazole
Severity: Moderate
Fluoxetine and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine may increase voriconazole concentrations, and voriconazole may in turn raise fluoxetine levels. Both can contribute to QT prolongation, and higher exposure raises the risk of voriconazole toxicity such as visual disturbances, hepatotoxicity and arrhythmia.
What this interaction means in plain words
Fluoxetine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluoxetine belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Fluoxetine inhibits CYP2C19 and CYP3A4, and voriconazole inhibits CYP2C19, CYP2D6 and CYP3A4, so reciprocal metabolism is reduced.
What to do
Monitor ECG, liver function and voriconazole trough levels, and watch for fluoxetine adverse effects; consider an alternative antidepressant if QT risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Fluoxetine with Voriconazole?
MediHelp rates the interaction as moderate. Fluoxetine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoxetine may increase voriconazole concentrations, and voriconazole may in turn raise fluoxetine levels. Both can contribute to QT prolongation, and higher exposure raises the risk of voriconazole toxicity such as visual disturbances, hepatotoxicity and arrhythmia.
How serious is the interaction between Fluoxetine and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, liver function and voriconazole trough levels, and watch for fluoxetine adverse effects; consider an alternative antidepressant if QT risk is high.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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