Drug interactions
Fluphenazine + Fluticasone-vilanterol
Severity: Moderate
Fluphenazine and Fluticasone-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine, a phenothiazine, can prolong the QT interval and vilanterol may add to arrhythmia risk. Risk is greater with electrolyte disturbance or cardiac disease.
What this interaction means in plain words
Fluphenazine and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Additive QTc prolongation via hERG blockade and beta-agonist adrenergic and hypokalemic effects.
What to do
Obtain ECG at baseline in at-risk patients and monitor potassium and magnesium. Reassess if palpitations, syncope or QTc prolongation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Fluticasone-vilanterol?
MediHelp rates the interaction as moderate. Fluphenazine and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine, a phenothiazine, can prolong the QT interval and vilanterol may add to arrhythmia risk. Risk is greater with electrolyte disturbance or cardiac disease.
How serious is the interaction between Fluphenazine and Fluticasone-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECG at baseline in at-risk patients and monitor potassium and magnesium. Reassess if palpitations, syncope or QTc prolongation occurs.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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