Drug interactions
Fluphenazine + Fostemsavir
Severity: Moderate
Fluphenazine and Fostemsavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine can prolong the QT interval, and fostemsavir has caused QTc prolongation at supratherapeutic doses. Using them together could raise the risk of ventricular arrhythmias in patients with other risk factors.
What this interaction means in plain words
Fluphenazine and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Fostemsavir belongs to Anti Virals.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain an ECG at baseline and during therapy in patients with cardiac disease, electrolyte problems or other QT-prolonging drugs. Correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fluphenazine with Fostemsavir?
MediHelp rates the interaction as moderate. Fluphenazine and Fostemsavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine can prolong the QT interval, and fostemsavir has caused QTc prolongation at supratherapeutic doses. Using them together could raise the risk of ventricular arrhythmias in patients with other risk factors.
How serious is the interaction between Fluphenazine and Fostemsavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG at baseline and during therapy in patients with cardiac disease, electrolyte problems or other QT-prolonging drugs. Correct hypokalemia and hypomagnesemia.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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