Drug interactions
Fluphenazine + Glycopyrronium
Severity: Moderate
Fluphenazine and Glycopyrronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine has some anticholinergic activity, which adds to that of glycopyrronium and may cause dry mouth, constipation, urinary retention and tachycardia. The anticholinergic effect of fluphenazine is weaker than that of low-potency phenothiazines, so the additive effect is usually modest.
What this interaction means in plain words
Fluphenazine and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Glycopyrronium belongs to Respiratory.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic symptoms and bowel and bladder function, and reduce the glycopyrronium dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glycopyrronium
- Clozapine + Glycopyrronium Major
- Glycopyrronium + Potassium chloride Major
- Abobotulinumtoxina + Glycopyrronium Moderate
- Aclidinium + Glycopyrronium Moderate
- Amantadine + Glycopyrronium Moderate
- Amitriptyline + Glycopyrronium Moderate
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Glycopyrronium?
MediHelp rates the interaction as moderate. Fluphenazine and Glycopyrronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine has some anticholinergic activity, which adds to that of glycopyrronium and may cause dry mouth, constipation, urinary retention and tachycardia. The anticholinergic effect of fluphenazine is weaker than that of low-potency phenothiazines, so the additive effect is usually modest.
How serious is the interaction between Fluphenazine and Glycopyrronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms and bowel and bladder function, and reduce the glycopyrronium dose if they occur.
What other medicines interact with Glycopyrronium?
MediHelp also lists interactions of Glycopyrronium with, for example, Clozapine, Potassium chloride, Abobotulinumtoxina. The full list is on the Glycopyrronium page.
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