Drug interactions
Fluphenazine + Lapatinib
Severity: Moderate
Fluphenazine and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib and fluphenazine each have the potential to prolong the QT interval. Combined use may increase the risk of torsades de pointes, particularly in patients with other risk factors.
What this interaction means in plain words
Fluphenazine and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Lapatinib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization (QT interval).
What to do
Check a baseline ECG and electrolytes and correct potassium and magnesium deficits. Repeat ECG during treatment and avoid the combination in patients with congenital long QT syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Fluphenazine with Lapatinib?
MediHelp rates the interaction as moderate. Fluphenazine and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib and fluphenazine each have the potential to prolong the QT interval. Combined use may increase the risk of torsades de pointes, particularly in patients with other risk factors.
How serious is the interaction between Fluphenazine and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes and correct potassium and magnesium deficits. Repeat ECG during treatment and avoid the combination in patients with congenital long QT syndrome.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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