Drug interactions
Fluphenazine + Linezolid
Severity: Moderate
Fluphenazine and Linezolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid inhibits MAO and fluphenazine is a potent dopamine antagonist, so additive serotonergic effects and neuroleptic malignant syndrome features are theoretically possible. Clinical reports are scarce.
What this interaction means in plain words
Fluphenazine and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Linezolid belongs to Anti Bacterial.
Why it happens
Possible additive serotonergic and dopamine-blocking effects with MAO inhibition by linezolid.
What to do
Monitor for hyperthermia, rigidity, tremor, clonus, agitation and autonomic instability during linezolid therapy. Stop the drugs and treat supportively if suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Linezolid?
MediHelp rates the interaction as moderate. Fluphenazine and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid inhibits MAO and fluphenazine is a potent dopamine antagonist, so additive serotonergic effects and neuroleptic malignant syndrome features are theoretically possible. Clinical reports are scarce.
How serious is the interaction between Fluphenazine and Linezolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hyperthermia, rigidity, tremor, clonus, agitation and autonomic instability during linezolid therapy. Stop the drugs and treat supportively if suspected.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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