Drug interactions
Fluphenazine + Metaxalone
Severity: Moderate
Fluphenazine and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine can cause sedation and, with metaxalone, may produce additive drowsiness and psychomotor slowing. Dizziness and impaired coordination may raise fall risk.
What this interaction means in plain words
Fluphenazine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression.
What to do
Monitor for oversedation and dizziness, particularly at initiation or dose increases. Counsel on driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Metaxalone?
MediHelp rates the interaction as moderate. Fluphenazine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine can cause sedation and, with metaxalone, may produce additive drowsiness and psychomotor slowing. Dizziness and impaired coordination may raise fall risk.
How serious is the interaction between Fluphenazine and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and dizziness, particularly at initiation or dose increases. Counsel on driving and operating machinery.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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