Drug interactions
Fluphenazine + Methoxsalen
Severity: Moderate
Fluphenazine and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines are photosensitizing, and methoxsalen is used to deliberately sensitize skin to UVA light. Together they may increase the risk of severe phototoxic reactions such as burns and blistering.
What this interaction means in plain words
Fluphenazine and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Methoxsalen belongs to Anti Fungals.
Why it happens
Additive photosensitizing effects.
What to do
Counsel patients to strictly protect skin and eyes from sunlight and artificial UV exposure. Consider reducing UVA dose and monitor for phototoxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Fluphenazine with Methoxsalen?
MediHelp rates the interaction as moderate. Fluphenazine and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines are photosensitizing, and methoxsalen is used to deliberately sensitize skin to UVA light. Together they may increase the risk of severe phototoxic reactions such as burns and blistering.
How serious is the interaction between Fluphenazine and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to strictly protect skin and eyes from sunlight and artificial UV exposure. Consider reducing UVA dose and monitor for phototoxicity.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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