Drug interactions
Fluphenazine + Naratriptan
Severity: Moderate
Fluphenazine and Naratriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antipsychotics combined with serotonergic agents such as triptans have been associated with serotonin syndrome in rare reports, and dopamine blockade may increase the risk of neuroleptic malignant syndrome. The absolute risk appears low.
What this interaction means in plain words
Fluphenazine and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Naratriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic activity with dopamine receptor blockade; the mechanism is largely theoretical.
What to do
Monitor for agitation, tremor, hyperreflexia, hyperthermia and rigidity after starting or increasing either drug. Stop the triptan and treat promptly if serotonin toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluphenazine and Naratriptan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Naratriptan
- Almotriptan + Naratriptan Contraindicated
- Dihydroergotamine intranasal + Naratriptan Contraindicated
- Dihydroergotamine + Naratriptan Contraindicated
- Eletriptan + Naratriptan Contraindicated
- Ergoloid mesylates + Naratriptan Contraindicated
- Ergotamine + Naratriptan Contraindicated
Frequently asked questions
Can I take Fluphenazine with Naratriptan?
MediHelp rates the interaction as moderate. Fluphenazine and Naratriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antipsychotics combined with serotonergic agents such as triptans have been associated with serotonin syndrome in rare reports, and dopamine blockade may increase the risk of neuroleptic malignant syndrome. The absolute risk appears low.
How serious is the interaction between Fluphenazine and Naratriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperreflexia, hyperthermia and rigidity after starting or increasing either drug. Stop the triptan and treat promptly if serotonin toxicity is suspected.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
