Drug interactions
Fluphenazine + Primaquine
Severity: Moderate
Fluphenazine and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have the potential to prolong the QT interval, so their combination may raise the risk of ventricular arrhythmias. Patients with cardiac disease or electrolyte disturbances are at greater risk.
What this interaction means in plain words
Fluphenazine and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Primaquine belongs to Anti Parasitic.
Why it happens
Additive QTc prolongation.
What to do
Obtain a baseline ECG and correct electrolytes. Repeat the ECG during co-therapy and advise patients to report palpitations or fainting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Primaquine?
MediHelp rates the interaction as moderate. Fluphenazine and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have the potential to prolong the QT interval, so their combination may raise the risk of ventricular arrhythmias. Patients with cardiac disease or electrolyte disturbances are at greater risk.
How serious is the interaction between Fluphenazine and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolytes. Repeat the ECG during co-therapy and advise patients to report palpitations or fainting.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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