Drug interactions
Fluphenazine + Procarbazine
Severity: Moderate
Fluphenazine and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak monoamine oxidase inhibitory activity and CNS depressant effects, and combined use with a phenothiazine may cause excessive sedation. Serotonergic toxicity or neuroleptic malignant syndrome is a theoretical concern.
What this interaction means in plain words
Fluphenazine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
Additive CNS depression plus possible monoamine oxidase inhibition affecting serotonergic and dopaminergic pathways.
What to do
Monitor for oversedation, hypotension, agitation, fever and rigidity. Reduce the fluphenazine dose if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Fluphenazine with Procarbazine?
MediHelp rates the interaction as moderate. Fluphenazine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has weak monoamine oxidase inhibitory activity and CNS depressant effects, and combined use with a phenothiazine may cause excessive sedation. Serotonergic toxicity or neuroleptic malignant syndrome is a theoretical concern.
How serious is the interaction between Fluphenazine and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, hypotension, agitation, fever and rigidity. Reduce the fluphenazine dose if sedation is excessive.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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