Drug interactions
Fluphenazine + Quetiapine
Severity: Moderate
Fluphenazine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining these antipsychotics increases the risk of extrapyramidal symptoms, sedation, orthostatic hypotension and neuroleptic malignant syndrome. QT prolongation may also be additive.
What this interaction means in plain words
Fluphenazine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Additive dopamine D2 antagonism with overlapping sedative, alpha-blocking and QT effects.
What to do
Use the lowest effective doses and avoid unnecessary combination. Monitor for movement disorders, sedation, orthostatic blood pressure and QTc.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Fluphenazine with Quetiapine?
MediHelp rates the interaction as moderate. Fluphenazine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining these antipsychotics increases the risk of extrapyramidal symptoms, sedation, orthostatic hypotension and neuroleptic malignant syndrome. QT prolongation may also be additive.
How serious is the interaction between Fluphenazine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and avoid unnecessary combination. Monitor for movement disorders, sedation, orthostatic blood pressure and QTc.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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