Drug interactions
Fluphenazine + Ritonavir
Severity: Moderate
Fluphenazine and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir inhibits CYP2D6 and CYP3A4, which may raise fluphenazine exposure. Higher levels can increase sedation, extrapyramidal symptoms and QT-related risk.
What this interaction means in plain words
Fluphenazine and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir inhibits CYP2D6-mediated metabolism of fluphenazine, reducing its clearance.
What to do
Monitor for extrapyramidal symptoms, sedation and hypotension when starting or stopping ritonavir. Reduce the fluphenazine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Fluphenazine with Ritonavir?
MediHelp rates the interaction as moderate. Fluphenazine and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir inhibits CYP2D6 and CYP3A4, which may raise fluphenazine exposure. Higher levels can increase sedation, extrapyramidal symptoms and QT-related risk.
How serious is the interaction between Fluphenazine and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and hypotension when starting or stopping ritonavir. Reduce the fluphenazine dose if adverse effects appear.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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