Drug interactions
Fluphenazine + Secobarbital
Severity: Moderate
Fluphenazine and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the CNS, so combined use can increase sedation, hypotension and psychomotor impairment. Barbiturates may also reduce antipsychotic levels through enzyme induction.
What this interaction means in plain words
Fluphenazine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Secobarbital belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible induction of antipsychotic metabolism by the barbiturate.
What to do
Use the lowest effective doses and monitor for oversedation and orthostatic hypotension. Watch for loss of psychotic symptom control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Secobarbital?
MediHelp rates the interaction as moderate. Fluphenazine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the CNS, so combined use can increase sedation, hypotension and psychomotor impairment. Barbiturates may also reduce antipsychotic levels through enzyme induction.
How serious is the interaction between Fluphenazine and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation and orthostatic hypotension. Watch for loss of psychotic symptom control.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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