Drug interactions
Fluphenazine + Sertraline
Severity: Moderate
Fluphenazine and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline can inhibit CYP2D6 at higher doses, which may raise fluphenazine concentrations. This may increase extrapyramidal symptoms, sedation and other antipsychotic adverse effects.
What this interaction means in plain words
Fluphenazine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Dose-dependent inhibition of CYP2D6-mediated fluphenazine metabolism by sertraline.
What to do
Monitor for extrapyramidal symptoms and sedation, particularly when the sertraline dose is increased. Reduce the fluphenazine dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluphenazine and Sertraline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Sertraline?
MediHelp rates the interaction as moderate. Fluphenazine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline can inhibit CYP2D6 at higher doses, which may raise fluphenazine concentrations. This may increase extrapyramidal symptoms, sedation and other antipsychotic adverse effects.
How serious is the interaction between Fluphenazine and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms and sedation, particularly when the sertraline dose is increased. Reduce the fluphenazine dose if adverse effects emerge.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
