Drug interactions
Fluphenazine + Sumatriptan
Severity: Minor
Fluphenazine and Sumatriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antipsychotics with triptans have rarely been associated with serotonin syndrome, and dopamine blockade may raise neuroleptic malignant syndrome risk. The absolute risk is low.
What this interaction means in plain words
Fluphenazine and Sumatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluphenazine belongs to Central Nervous System; Sumatriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects with dopamine blockade; largely theoretical.
What to do
Counsel patients on symptoms of serotonin toxicity such as agitation, tremor, sweating and fever, and stop the triptan if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Fluphenazine with Sumatriptan?
MediHelp rates the interaction as minor. Fluphenazine and Sumatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antipsychotics with triptans have rarely been associated with serotonin syndrome, and dopamine blockade may raise neuroleptic malignant syndrome risk. The absolute risk is low.
How serious is the interaction between Fluphenazine and Sumatriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients on symptoms of serotonin toxicity such as agitation, tremor, sweating and fever, and stop the triptan if they occur.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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