Drug interactions
Fluphenazine + Terbinafine
Severity: Moderate
Fluphenazine and Terbinafine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine is cleared mainly by CYP2D6, so terbinafine can increase its plasma levels. This may intensify extrapyramidal symptoms, sedation, hypotension and QT effects.
What this interaction means in plain words
Fluphenazine and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Terbinafine belongs to Anti Fungals.
Why it happens
Terbinafine inhibits CYP2D6-mediated metabolism of fluphenazine.
What to do
Monitor for extrapyramidal symptoms, sedation and hypotension. Lower the fluphenazine dose if needed, and consider an alternative antifungal for non-urgent infections.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Terbinafine?
MediHelp rates the interaction as moderate. Fluphenazine and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine is cleared mainly by CYP2D6, so terbinafine can increase its plasma levels. This may intensify extrapyramidal symptoms, sedation, hypotension and QT effects.
How serious is the interaction between Fluphenazine and Terbinafine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and hypotension. Lower the fluphenazine dose if needed, and consider an alternative antifungal for non-urgent infections.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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