Drug interactions
Fluphenazine + Umeclidinium-vilanterol
Severity: Moderate
Fluphenazine and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine can prolong the QT interval and has anticholinergic activity. Combined with vilanterol cardiac effects and umeclidinium, arrhythmia risk and anticholinergic effects may increase.
What this interaction means in plain words
Fluphenazine and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluphenazine belongs to Central Nervous System; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive QT prolongation, beta-agonist cardiac stimulation and anticholinergic effects.
What to do
Monitor ECG in patients with cardiac risk factors, and check potassium and magnesium. Watch for anticholinergic effects such as urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Fluphenazine with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Fluphenazine and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine can prolong the QT interval and has anticholinergic activity. Combined with vilanterol cardiac effects and umeclidinium, arrhythmia risk and anticholinergic effects may increase.
How serious is the interaction between Fluphenazine and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac risk factors, and check potassium and magnesium. Watch for anticholinergic effects such as urinary retention.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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