Drug interactions
Flurazepam + Lisdexamfetamine
Severity: Minor
Flurazepam and Lisdexamfetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lisdexamfetamine is a stimulant and flurazepam is a long-acting benzodiazepine hypnotic, so their effects on alertness oppose each other. The stimulant may mask flurazepam sedation without removing its psychomotor impairment, and the net effect is unpredictable.
What this interaction means in plain words
Flurazepam and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic effects on CNS arousal (stimulant versus GABA-A mediated sedation); no pharmacokinetic interaction is established.
What to do
Counsel the patient not to rely on perceived alertness when driving or operating machinery. Reassess the need for each drug if insomnia or excessive stimulation develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Flurazepam and Lisdexamfetamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Flurazepam with Lisdexamfetamine?
MediHelp rates the interaction as minor. Flurazepam and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lisdexamfetamine is a stimulant and flurazepam is a long-acting benzodiazepine hypnotic, so their effects on alertness oppose each other. The stimulant may mask flurazepam sedation without removing its psychomotor impairment, and the net effect is unpredictable.
How serious is the interaction between Flurazepam and Lisdexamfetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient not to rely on perceived alertness when driving or operating machinery. Reassess the need for each drug if insomnia or excessive stimulation develops.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
