Drug interactions
Flurazepam + Metoclopramide
Severity: Moderate
Flurazepam and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause sedation, so combined use may increase drowsiness and psychomotor impairment. Metoclopramide may also speed absorption of oral benzodiazepines through faster gastric emptying.
What this interaction means in plain words
Flurazepam and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with faster gastric emptying possibly increasing benzodiazepine absorption.
What to do
Monitor for oversedation, particularly in older adults, and use the lowest effective doses. Advise against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Frequently asked questions
Can I take Flurazepam with Metoclopramide?
MediHelp rates the interaction as moderate. Flurazepam and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause sedation, so combined use may increase drowsiness and psychomotor impairment. Metoclopramide may also speed absorption of oral benzodiazepines through faster gastric emptying.
How serious is the interaction between Flurazepam and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, particularly in older adults, and use the lowest effective doses. Advise against driving and alcohol.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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