Drug interactions
Flurazepam + Propofol
Severity: Moderate
Flurazepam and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam is a long-acting benzodiazepine hypnotic with active metabolites, and combining it with propofol produces additive sedation and respiratory depression. Effects may be prolonged, particularly in older adults.
What this interaction means in plain words
Flurazepam and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive GABA-A receptor-mediated CNS depression.
What to do
Use a reduced propofol dose with slow titration and monitor oxygenation, ventilation and sedation level through recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Frequently asked questions
Can I take Flurazepam with Propofol?
MediHelp rates the interaction as moderate. Flurazepam and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurazepam is a long-acting benzodiazepine hypnotic with active metabolites, and combining it with propofol produces additive sedation and respiratory depression. Effects may be prolonged, particularly in older adults.
How serious is the interaction between Flurazepam and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced propofol dose with slow titration and monitor oxygenation, ventilation and sedation level through recovery.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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