Drug interactions
Flurbiprofen + Glipizide
Severity: Moderate
Flurbiprofen and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen may enhance the glucose-lowering effect of glipizide and raise the chance of hypoglycemia. Flurbiprofen is highly protein bound and is cleared by CYP2C9, the same pathway used by glipizide, so both drugs can compete. The effect is variable and usually modest.
What this interaction means in plain words
Flurbiprofen and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Glipizide belongs to Endocrine.
Why it happens
Possible competition for CYP2C9 metabolism and plasma protein binding, which may raise free sulfonylurea concentrations.
What to do
Monitor blood glucose when flurbiprofen is started or stopped in patients taking glipizide, and counsel on hypoglycemia symptoms. Reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Glipizide
Frequently asked questions
Can I take Flurbiprofen with Glipizide?
MediHelp rates the interaction as moderate. Flurbiprofen and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurbiprofen may enhance the glucose-lowering effect of glipizide and raise the chance of hypoglycemia. Flurbiprofen is highly protein bound and is cleared by CYP2C9, the same pathway used by glipizide, so both drugs can compete. The effect is variable and usually modest.
How serious is the interaction between Flurbiprofen and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when flurbiprofen is started or stopped in patients taking glipizide, and counsel on hypoglycemia symptoms. Reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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