Drug interactions
Flurbiprofen + Hydrochlorothiazide-irbesartan
Severity: Moderate
Flurbiprofen and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen can reduce the blood pressure lowering effect of irbesartan and hydrochlorothiazide. Together with an ARB and a diuretic it increases the risk of acute kidney injury and hyperkalemia, particularly in older or volume-depleted patients.
What this interaction means in plain words
Flurbiprofen and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and sodium excretion while ARB and diuretic reduce glomerular filtration pressure.
What to do
Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Prefer the lowest effective NSAID dose for a short duration or an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Flurbiprofen with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Flurbiprofen and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurbiprofen can reduce the blood pressure lowering effect of irbesartan and hydrochlorothiazide. Together with an ARB and a diuretic it increases the risk of acute kidney injury and hyperkalemia, particularly in older or volume-depleted patients.
How serious is the interaction between Flurbiprofen and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Prefer the lowest effective NSAID dose for a short duration or an alternative analgesic.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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