Drug interactions
Flurbiprofen + Levoketoconazole
Severity: Minor
Flurbiprofen and Levoketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole may raise flurbiprofen levels by inhibiting its metabolism. Higher exposure may increase the risk of NSAID toxicity, though CYP2C9 inhibition by ketoconazole is relatively weak.
What this interaction means in plain words
Flurbiprofen and Levoketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Flurbiprofen belongs to Musculoskeletal; Levoketoconazole belongs to Endocrine.
Why it happens
Inhibition of hepatic CYP2C9 metabolism of flurbiprofen.
What to do
Monitor for GI bleeding, fluid retention and renal changes; use the lowest effective flurbiprofen dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Flurbiprofen with Levoketoconazole?
MediHelp rates the interaction as minor. Flurbiprofen and Levoketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Levoketoconazole may raise flurbiprofen levels by inhibiting its metabolism. Higher exposure may increase the risk of NSAID toxicity, though CYP2C9 inhibition by ketoconazole is relatively weak.
How serious is the interaction between Flurbiprofen and Levoketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding, fluid retention and renal changes; use the lowest effective flurbiprofen dose.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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