Drug interactions
Flurbiprofen + Trazodone
Severity: Moderate
Flurbiprofen and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has serotonergic activity that can impair platelet function, and flurbiprofen also inhibits platelets and irritates the gastric mucosa. Together they raise the risk of bleeding, particularly from the upper gastrointestinal tract.
What this interaction means in plain words
Flurbiprofen and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Trazodone belongs to Central Nervous System.
Why it happens
Additive impairment of platelet aggregation, with NSAID-related mucosal injury, from reduced platelet serotonin uptake and COX-1 inhibition.
What to do
Watch for signs of gastrointestinal bleeding, especially in older patients or those with ulcer history or on anticoagulants. Consider a proton pump inhibitor for gastroprotection if long-term use is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Flurbiprofen with Trazodone?
MediHelp rates the interaction as moderate. Flurbiprofen and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone has serotonergic activity that can impair platelet function, and flurbiprofen also inhibits platelets and irritates the gastric mucosa. Together they raise the risk of bleeding, particularly from the upper gastrointestinal tract.
How serious is the interaction between Flurbiprofen and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for signs of gastrointestinal bleeding, especially in older patients or those with ulcer history or on anticoagulants. Consider a proton pump inhibitor for gastroprotection if long-term use is needed.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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