Drug interactions
Flurbiprofen + Vortioxetine
Severity: Moderate
Flurbiprofen and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vortioxetine is a serotonergic antidepressant that can impair platelet function, and flurbiprofen adds antiplatelet and gastric-irritant effects. Combined use increases the likelihood of bruising and gastrointestinal or other bleeding.
What this interaction means in plain words
Flurbiprofen and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Vortioxetine belongs to Central Nervous System.
Why it happens
Additive platelet dysfunction from reduced platelet serotonin uptake and COX-1 inhibition.
What to do
Monitor for signs of bleeding and consider a proton pump inhibitor in patients with additional risk factors. Prefer the lowest effective NSAID dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Flurbiprofen with Vortioxetine?
MediHelp rates the interaction as moderate. Flurbiprofen and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vortioxetine is a serotonergic antidepressant that can impair platelet function, and flurbiprofen adds antiplatelet and gastric-irritant effects. Combined use increases the likelihood of bruising and gastrointestinal or other bleeding.
How serious is the interaction between Flurbiprofen and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and consider a proton pump inhibitor in patients with additional risk factors. Prefer the lowest effective NSAID dose for the shortest duration.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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