Drug interactions
Flutamide + Ribociclib
Severity: Moderate
Flutamide and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate CYP3A4 inhibitor and may raise exposure to CYP-metabolized drugs. Flutamide is mainly metabolized by CYP1A2, so the effect is uncertain, though hepatotoxicity from both drugs is additive in concern.
What this interaction means in plain words
Flutamide and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flutamide belongs to Endocrine; Ribociclib belongs to Oncology.
Why it happens
Ribociclib inhibits CYP3A4, which may modestly affect flutamide metabolism; both drugs can also cause hepatotoxicity.
What to do
Monitor liver function tests regularly during combined use and stop therapy if significant transaminase elevations occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flutamide
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Flutamide with Ribociclib?
MediHelp rates the interaction as moderate. Flutamide and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate CYP3A4 inhibitor and may raise exposure to CYP-metabolized drugs. Flutamide is mainly metabolized by CYP1A2, so the effect is uncertain, though hepatotoxicity from both drugs is additive in concern.
How serious is the interaction between Flutamide and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests regularly during combined use and stop therapy if significant transaminase elevations occur.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
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