Drug interactions
Fluticasone + Letermovir
Severity: Moderate
Fluticasone and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir is a moderate CYP3A inhibitor and may modestly increase fluticasone exposure. Systemic steroid effects are possible with prolonged use.
What this interaction means in plain words
Fluticasone and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone belongs to Respiratory; Letermovir belongs to Anti Virals.
Why it happens
Letermovir inhibits CYP3A4, reducing fluticasone clearance.
What to do
Monitor for Cushingoid effects and adrenal suppression with prolonged use. Consider beclomethasone if long-term therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Fluticasone with Letermovir?
MediHelp rates the interaction as moderate. Fluticasone and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir is a moderate CYP3A inhibitor and may modestly increase fluticasone exposure. Systemic steroid effects are possible with prolonged use.
How serious is the interaction between Fluticasone and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for Cushingoid effects and adrenal suppression with prolonged use. Consider beclomethasone if long-term therapy is needed.
What other medicines interact with Fluticasone?
MediHelp also lists interactions of Fluticasone with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Fluticasone page.
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