Drug interactions
Fluticasone + Ribociclib
Severity: Moderate
Fluticasone and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib is a moderate-to-strong CYP3A4 inhibitor and could increase systemic fluticasone exposure. Prolonged exposure may lead to Cushingoid effects and adrenal suppression.
What this interaction means in plain words
Fluticasone and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone belongs to Respiratory; Ribociclib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 metabolism of fluticasone by ribociclib.
What to do
Monitor for signs of corticosteroid excess during long-term use and consider an alternative such as beclometasone if prolonged coadministration is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Fluticasone with Ribociclib?
MediHelp rates the interaction as moderate. Fluticasone and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib is a moderate-to-strong CYP3A4 inhibitor and could increase systemic fluticasone exposure. Prolonged exposure may lead to Cushingoid effects and adrenal suppression.
How serious is the interaction between Fluticasone and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess during long-term use and consider an alternative such as beclometasone if prolonged coadministration is needed.
What other medicines interact with Fluticasone?
MediHelp also lists interactions of Fluticasone with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Fluticasone page.
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