Drug interactions
Fluticasone + Tipranavir
Severity: Major
Fluticasone and Tipranavir: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir is given with ritonavir, which strongly inhibits CYP3A4 and increases systemic fluticasone exposure. Prolonged use may lead to Cushing's syndrome and adrenal suppression.
What this interaction means in plain words
Fluticasone and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone belongs to Respiratory; Tipranavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted tipranavir inhibits CYP3A4 metabolism of fluticasone.
What to do
Prefer a non-CYP3A4-dependent corticosteroid such as beclomethasone. If unavoidable, monitor for Cushingoid signs and adrenal suppression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluticasone
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Fluticasone with Tipranavir?
MediHelp rates the interaction as major. Fluticasone and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir is given with ritonavir, which strongly inhibits CYP3A4 and increases systemic fluticasone exposure. Prolonged use may lead to Cushing's syndrome and adrenal suppression.
How serious is the interaction between Fluticasone and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-CYP3A4-dependent corticosteroid such as beclomethasone. If unavoidable, monitor for Cushingoid signs and adrenal suppression.
What other medicines interact with Fluticasone?
MediHelp also lists interactions of Fluticasone with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Fluticasone page.
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