Drug interactions
Fluticasone + Voriconazole
Severity: Major
Fluticasone and Voriconazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole is a strong CYP3A4 inhibitor and may considerably increase systemic exposure to fluticasone. Adrenal suppression and Cushing syndrome are possible, mainly with prolonged use.
What this interaction means in plain words
Fluticasone and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fluticasone belongs to Respiratory; Voriconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition by voriconazole reduces metabolism of fluticasone.
What to do
Avoid prolonged coadministration where possible and consider an alternative corticosteroid such as beclometasone. If used together, monitor for Cushingoid features and adrenal suppression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluticasone
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Fluticasone with Voriconazole?
MediHelp rates the interaction as major. Fluticasone and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole is a strong CYP3A4 inhibitor and may considerably increase systemic exposure to fluticasone. Adrenal suppression and Cushing syndrome are possible, mainly with prolonged use.
How serious is the interaction between Fluticasone and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged coadministration where possible and consider an alternative corticosteroid such as beclometasone. If used together, monitor for Cushingoid features and adrenal suppression.
What other medicines interact with Fluticasone?
MediHelp also lists interactions of Fluticasone with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Fluticasone page.
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