Drug interactions
Fluticasone furoate + Posaconazole
Severity: Major
Fluticasone furoate and Posaconazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole is a strong CYP3A4 inhibitor and can increase systemic fluticasone furoate exposure. Adrenal suppression and Cushing's syndrome are possible with prolonged co-use.
What this interaction means in plain words
Fluticasone furoate and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Strong CYP3A4 inhibition by posaconazole reduces fluticasone furoate clearance.
What to do
Avoid prolonged co-administration where feasible or use a corticosteroid less reliant on CYP3A4. If combined, monitor for hypercortisolism and adrenal suppression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Fluticasone furoate with Posaconazole?
MediHelp rates the interaction as major. Fluticasone furoate and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole is a strong CYP3A4 inhibitor and can increase systemic fluticasone furoate exposure. Adrenal suppression and Cushing's syndrome are possible with prolonged co-use.
How serious is the interaction between Fluticasone furoate and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged co-administration where feasible or use a corticosteroid less reliant on CYP3A4. If combined, monitor for hypercortisolism and adrenal suppression.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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