Drug interactions
Fluticasone furoate + Tucatinib
Severity: Moderate
Fluticasone furoate and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a moderate CYP3A inhibitor and can increase exposure to CYP3A substrates such as fluticasone furoate. This raises the chance of systemic corticosteroid effects like adrenal suppression, mostly with prolonged use.
What this interaction means in plain words
Fluticasone furoate and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 reduces metabolism of fluticasone furoate.
What to do
Monitor for systemic corticosteroid effects during long-term co-administration. Consider an alternative corticosteroid such as beclomethasone if prolonged use is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Fluticasone furoate with Tucatinib?
MediHelp rates the interaction as moderate. Fluticasone furoate and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib is a moderate CYP3A inhibitor and can increase exposure to CYP3A substrates such as fluticasone furoate. This raises the chance of systemic corticosteroid effects like adrenal suppression, mostly with prolonged use.
How serious is the interaction between Fluticasone furoate and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for systemic corticosteroid effects during long-term co-administration. Consider an alternative corticosteroid such as beclomethasone if prolonged use is needed.
What other medicines interact with Tucatinib?
MediHelp also lists interactions of Tucatinib with, for example, Cisapride, Eletriptan, Ergotamine. The full list is on the Tucatinib page.
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