Drug interactions
Fluticasone inhaled + Posaconazole
Severity: Major
Fluticasone inhaled and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 inhibitors markedly increase systemic fluticasone exposure, and the resulting corticosteroid excess can cause Cushing's syndrome and adrenal suppression. This has been reported with ritonavir and azole antifungals, and the risk rises with prolonged use.
What this interaction means in plain words
Fluticasone inhaled and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Posaconazole inhibits CYP3A4, which normally clears swallowed and absorbed fluticasone, increasing systemic exposure.
What to do
Avoid long-term coadministration where possible and consider an alternative such as beclomethasone. If combined, monitor for signs of hypercortisolism and adrenal suppression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Fluticasone inhaled with Posaconazole?
MediHelp rates the interaction as major. Fluticasone inhaled and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Strong CYP3A4 inhibitors markedly increase systemic fluticasone exposure, and the resulting corticosteroid excess can cause Cushing's syndrome and adrenal suppression. This has been reported with ritonavir and azole antifungals, and the risk rises with prolonged use.
How serious is the interaction between Fluticasone inhaled and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term coadministration where possible and consider an alternative such as beclomethasone. If combined, monitor for signs of hypercortisolism and adrenal suppression.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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