Drug interactions
Fluticasone intranasal + Posaconazole
Severity: Moderate
Fluticasone intranasal and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can increase systemic fluticasone exposure, as seen with other strong CYP3A4 inhibitors. Prolonged use may cause Cushing's syndrome and adrenal suppression.
What this interaction means in plain words
Fluticasone intranasal and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Strong CYP3A4 inhibition reduces first-pass and systemic clearance of fluticasone.
What to do
For long-term coadministration, consider an alternative such as beclomethasone and monitor for Cushingoid features and adrenal suppression. Short courses usually need only awareness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Fluticasone intranasal with Posaconazole?
MediHelp rates the interaction as moderate. Fluticasone intranasal and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole can increase systemic fluticasone exposure, as seen with other strong CYP3A4 inhibitors. Prolonged use may cause Cushing's syndrome and adrenal suppression.
How serious is the interaction between Fluticasone intranasal and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For long-term coadministration, consider an alternative such as beclomethasone and monitor for Cushingoid features and adrenal suppression. Short courses usually need only awareness.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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