Drug interactions
Fluticasone-salmeterol + Hydrochlorothiazide
Severity: Moderate
Fluticasone-salmeterol and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics and beta-2 agonists both lower serum potassium, so combined use may cause hypokalemia and, in susceptible patients, arrhythmias. The effect is usually modest with inhaled doses.
What this interaction means in plain words
Fluticasone-salmeterol and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-salmeterol belongs to Respiratory; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive hypokalemia from renal potassium loss and beta-2-mediated intracellular potassium shift.
What to do
Monitor serum potassium, especially with high-dose beta-agonist use or acute exacerbations. Supplement potassium if low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Fluticasone-salmeterol with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics and beta-2 agonists both lower serum potassium, so combined use may cause hypokalemia and, in susceptible patients, arrhythmias. The effect is usually modest with inhaled doses.
How serious is the interaction between Fluticasone-salmeterol and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially with high-dose beta-agonist use or acute exacerbations. Supplement potassium if low.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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